What is dimerization of a receptor?
Dimerization is a well-established regulatory mechanism for single membrane-spanning receptors [6,7], which may be involved in regulation of RPTPs. Mutation of a single residue in the wedge of CD45 abolishes dimerization-induced functional inactivation [16].
Where are GR receptors located?
cytoplasm
Human GRa is expressed virtually in all organs and tissues, resides primarily in the cytoplasm, and represents the classic glucocorticoid receptor that functions as a ligand-dependent transcription factor.
What is a glucocorticoid response?
Glucocorticoids are hormones essential for life that are synthesized and released by the adrenal cortex in a circadian manner and in response to stress. The secretion of these hormones is controlled by the hypothalamic-pituitary-adrenal (HPA) axis (Figure 1).
What is the meaning of dimerisation?
A dimerization is an addition reaction in which two molecules of the same compound react with each other to give the adduct.
What is the process of dimerization?
What is dimerization? It is a process where two molecules of similar chemical composition come together to form a single polymer known as a dimer. Where does dimerization occur? In the nucleus, hormone receptors, acting as transcription factors, form dimers to increase stability and improve binding to DNA.
What is the difference between a glucocorticoid and a mineralocorticoid?
Mineralocorticoids and glucocorticoids are key steroid hormones secreted by the adrenal cortex. These hormones are vital for life with mineralocorticoids regulating the water and electrolyte balance, whilst glucocorticoids control body homeostasis, stress and immune responses.
What are the mineralocorticoid hormones?
Mineralocorticoids are a class of steroid hormones that influence salt and water balance. The primary mineralocorticoid is aldosterone, but other endogenous hormones such as progesterone and deoxycorticosterone have mineralocorticoid function.
What does dimerization of a receptor mean?
Dimerization Dimerization leads to transphosphorylation of the tyrosine kinase domains of the receptor with signaling via downstream intracellular pathways leading to cell activation and proliferation. From: Her2-Positive Breast Cancer, 2019
What is the meaning of receptor?
Definition of receptor : receiver: such as a : a cell or group of cells that receives stimuli : sense organ b : a chemical group or molecule (such as a protein) on the cell surface or in the cell interior that has an affinity for a specific chemical group, molecule, or virus
What is a dimer in biology?
In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound. Many macromolecules, such as proteins or nucleic acids, form dimers. The word dimer has roots meaning “two parts”, di- + -mer.
What is meant by dimerization of membrane protein interfaces?
Dimerization of membrane protein interfaces occurs during membrane protein folding and cell receptor signaling.