What is cyclic neutropenia?
Cyclic neutropenia is a rare syndrome of recurrent neutropenia (typically every three weeks) and associated symptoms, including fever, malaise, mucosal ulcerations, and occasional abdominal discomfort; affected individuals are generally well between episodes.
How is cyclic neutropenia treated?
What are the treatments for cyclic neutropenia (CyN)? Treatments for CyN include: Antibiotics for infections. Granulocyte colony-stimulating factor (G-CSF), filgrastim (Neupogen®)
How common is cyclic neutropenia?
Cyclic neutropenia is a rare condition and is estimated to occur in 1 in 1 million individuals worldwide.
Is cyclic neutropenia an autoimmune disease?
The most common is chronic benign neutropenia of childhood, which may be an autoimmune disease. Chronic idiopathic neutropenia in adults is also acquired. It occurs predominantly in adolescent girls and women, beginning at approximately age 15 and usually lasting, in terms of its initial onset, until the mid-30s.
Can neutropenia lead to leukemia?
Lower doses administered more frequently can lessen side effects. Prolonged use of G-CSF in congenital neutropenias has been associated with development of pre-leukemia or leukemia, but this complication is extremely rare in cyclic neutropenia and has not been reported in autoimmune or idiopathic neutropenias.
Does neutropenia mean leukemia?
Although patients with leukemia may have very high white blood cell counts, the leukemia cells don’t protect against infection the way normal white blood cells do. Neutropenia means that the level of normal neutrophils is low.
How is cyclic neutropenia diagnosed?
The diagnosis of cyclic neutropenia is often confirmed by blood work including measurement of an absolute neutrophil count that is less than 200/microL during periods of neutropenia on multiple days within at least 3 regularly spaced cycles. Genetic testing can additionally be helpful to confirm the diagnosis.
What are the signs and symptoms of neutropenia?
low-grade fever,
What is the abbreviation for cyclic neutropenia?
Cyclic neutropenia ( CyN) is a rare hematologic disorder and form of congenital neutropenia that tends to occur approximately every three weeks and lasting for few days at a time due to changing rates of neutrophil production by the bone marrow.
Is cyclic neutropenia contagious?
Cyclic neutropenia is not related to infection. About contagion and contagiousness: Contagion and contagiousness refers to how easily the spread of Cyclic neutropenia is possible from one person to another. Other words for contagion include “infection”, “infectiousness”, “transmission” or “transmissability”.
What is severe neutropenia?
Severe congenital neutropenia describes a condition where an individual is born with severe neutropenia (defined as neutrophil count < 500 cells per microliter, often < 200). One specific form is called Kostmann Syndrome.