What is the difference between meropenem and imipenem?
In general, imipenem is more active against Gram-positive cocci while meropenem is more active against Gram-negative bacilli. The agents display similar pharmacokinetics.
Why meropenem is better than imipenem?
Against Enterobacteriaceae, meropenem is four- to 16-fold more active than imipenem. Meropenem is approximately eightfold more active than imipenem against Haemophilus influenzae and Neisseria gonorrhoeae. B cepacia displays intermediate resistance, and S maltophilia is resistant to both agents.
Is imipenem better than meropenem?
The two drugs produced similar satisfactory clinical response rates against LRTIs: 68.3% (41/60) with meropenem versus 68.6% (35/51) with imipenem/cilastatin. Meropenem appeared to be slightly more effective against intra-abdominal infections: 95.5% (21/22) versus 76.7% (23/30), respectively.
What is similar to meropenem?
Meropenem Alternatives Compared
| Meropenem | Cephalexin |
|---|---|
| Brand Names | |
| Merrem | Keflex |
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |
| 1 hour | 1 hour |
What type of antibiotic is imipenem?
Imipenem is in a class of medications called carbapenem antibiotics. It works by killing bacteria. Cilastatin is in a class of medications called dehydropeptidase inhibitors.
Does meropenem cover Gram-positive?
Meropenem is a broad-spectrum carbapenem antibiotic that possesses excellent activity against both aerobic Gram-positive and aerobic Gram-negative bacteria, and also covers common anaerobes.
What class of antibiotic is imipenem?
What class of drug is imipenem?
Imipenem is in a class of medications called carbapenem antibiotics. It works by killing bacteria. Cilastatin is in a class of medications called dehydropeptidase inhibitors. It works by helping imipenem stay active in your body for a longer period of time.
What is the mechanism of action of imipenem?
Imipenem + cilastatin is a beta-lactam antibiotic of the carbapenems class with a broad spectrum of activity. The mechanism of action is similar to the other beta-lactam antibiotics, which is to inactivate the penicillin-binding proteins (PBP) and cause cell wall lysis, or interfere with cell wall formation.
Is imipenem more cost effective than meropenem for severe infections?
CONCLUSIONS: Current literature supports the use of imipenem at a dose of 500 mg every 6 h and meropenem at 1 g every 8 h for the treatment of severe infections. For the treatment of serious infections, imipenem (500 mg every 6 h or 2 g/day [$98/day]) is more economical than meropenem (1 g every 8 h or 3 g/day [$142/day]) based on acquisition cost.
What is the difference between carbapenem and imipenem?
Imipenem, the first carbapenem, was first marketed in 1987; meropenem was introduced to the market in 1996. In general, imipenem is more active against Gram-positive cocci while meropenem is more active against Gram-negative bacilli. The agents display similar pharmacokinetics.
Does meropenem cause seizures in meningitis?
As mentioned previously, in one small clinical trial of meningitis, imipenem was associated with a 33% incidence of seizures (91). In contrast, both animal data and noncomparative clinical trials demonstrate that meropenem has a lower propensity than imipenem to cause seizures (105,107).
What is the half life of imipenem?
Approximately 70% of meropenem is renally eliminated as the parent compound. tion. Imipenem’s half-life increases to 4 h and meropenem’s to (Table 4). Both imipenem and meropenem are removed by di