How do you administer IV pentamidine?
Pentamidine injection comes as powder to be mixed with liquid to be injected intramuscularly (into a muscle) or intravenously (into a vein) by a doctor or nurse in a medical facility. If it is given intravenously, then it is usually given as a slow infusion over 60 to 120 minutes.
How do you reconstitute pentamidine?
Reconstitution. The contents of one vial (300 mg) must be dissolved in 6 mL Sterile Water for Injection, USP. Place the entire reconstituted contents of the vial into the Respirgard® II nebulizer reservoir for administration.
What is pentamidine IV?
Pentamidine is used to treat a serious lung infection (Pneumocystis pneumonia-PCP) in people with immune system problems, including people with acquired immunodeficiency syndrome (AIDS). Pentamidine belongs to a class of drugs known as antiprotozoals. It works by killing the organism that causes the infection.
Does pentamidine cause neutropenia?
In a few cases, pentamidine isetionate therapy has been associated with neutropenia. Abnormal liver function tests may occur. Liver function should be routinely monitored in patients receiving Pentamidine Isetionate for Injection BP (see WARNINGS AND PRECAUTIONS: Monitoring and Laboratory Tests).
How do you administer suramin?
Suramin is administered intravenously. The adult dose is 100 to 200 mg (test dose), then 1 g on days 1, 3, 7, 14, and 21. The pediatric dose is 20 mg/kg on days 1, 3, 7, 14, and 21. Suramin has an extremely long half-life in humans (44 to 54 days), which is the result of avid binding to serum proteins.
How long does IV pentamidine last?
Pentamidine is given intravenously or inhaled as an aerosol for P. jirovecii pneumonia. It can be given by deep intramuscular injection for leishmaniasis or trypanosomiasis. Pentamidine is metabolised in the liver and has a very long half-life (10–14 days).
Can NebuPent be given IV?
(See PRECAUTIONS). Available clinical pharmacology data (see CLINICAL PHARMACOLOGY) suggest that a dose up to 40 times the recommended NebuPent dosage would be required to produce systemic levels similar to a single 4 mg/kg intravenous dose.
Is pentamidine a chemo drug?
Pentamidine is an antibiotic used for pneumonia treatment. Drugs used in chemotherapy, such as ifosfamide, carboplatin and etoposide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
What is pentamidine nebuliser?
Pentamidine isethionate (NebuPent®, Pentam®) is used to prevent and treat Pneumocystis carinii pneumonia, a very serious type of pneumonia, following liver transplantation. It may be prescribed for patients who cannot take Bactrim®.
What are the side effects of suramin?
Side Effects
- Cloudy urine.
- crawling or tingling sensation of the skin.
- faintness, especially after missing meals.
- increased skin color.
- itching.
- joint pain.
- numbness or weakness in arms, hands, legs, or feet.
- skin rash.
What is a pentamidine injection?
Pentamidine Injection Description. Pentamidine isethionate for injection, an anti-protozoal agent, is a sterile, nonpyrogenic, lyophilized product. After reconstitution, it should be administered by intramuscular (IM) or intravenous (IV) routes (see DOSAGE AND ADMINISTRATION).
How do you administer intramuscular Pentamidine isethionate?
Pentamidine isethionate for injection, an anti-protozoal agent, is a sterile, nonpyrogenic, lyophilized product. After reconstitution, it should be administered by intramuscular (IM) or intravenous (IV) routes (see DOSAGE AND ADMINISTRATION ).
What is the plasma concentration of pentamidine in im?
In seven patients treated with daily IM doses of pentamidine at 4 mg/kg for 10 to 12 days, plasma concentrations were between 300 to 500 ng/mL. The concentrations did not appreciably change with time after injection or from day to day. Higher plasma concentrations were encountered in patients with an elevated blood urea nitrogen.
How much Pentamidine isethionate should be given to a patient with AIDS?
Following multiple intravenous administration of pentamidine isethionate (3.7 to 4 mg/kg/day infused over 4 hours) to 6 patients with AIDS being treated for PCP, the pharmacokinetic parameters obtained on Days 1, 4 and 7 are summarized in the following table:
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